{"id":173932,"date":"2014-01-13T16:12:49","date_gmt":"2014-01-13T21:12:49","guid":{"rendered":"https:\/\/dev.totemweb.design\/macommunaute\/evenements\/u10131-conference-de-la-professeure-hanadi-sleiman-mcgill\/"},"modified":"2014-01-13T16:12:49","modified_gmt":"2014-01-13T21:12:49","slug":"u10131-conference-de-la-professeure-hanadi-sleiman-mcgill","status":"publish","type":"evenements","link":"https:\/\/dev.totemweb.design\/macommunaute\/evenements\/u10131-conference-de-la-professeure-hanadi-sleiman-mcgill\/","title":{"rendered":"Conf\u00e9rence de la Professeure Hanadi Sleiman (McGill)"},"content":{"rendered":"<div>\n<p><strong>Titre :<\/strong>\u00a0 Three-Dimensional DNA Structures for Biological and Materials Applications<strong>.<\/strong><\/p>\n<p>La conf\u00e9rence sera prononc\u00e9e par la professeure <strong>Hanadi Sleiman <\/strong>du D\u00e9partement de chimie de l&rsquo;Universit\u00e9 McGill. Elle sera donn\u00e9e en anglais.\u00a0<\/p>\n<p><strong>R\u00e9sum\u00e9 :<\/strong> Three-dimensional structures made of DNA hold the potential to encapsulate and release drugs, regulate the assembly and activity of proteins,and organize networks for catalysis and biomolecule crystallization.\u00a0 This talk will describe our research group\u2019s synthetic approaches to 3D-DNA structures, such as DNA cages and nanotubes.\u00a0 These can be accessed with deliberate variation of geometry, size, single- and double-stranded forms, permeability and length.\u00a0 They can be dynamically switched to different internal volumes, and can be \u2018opened\u2019 or closed with specific DNA strands. The size-selective encapsulation of nanoparticles and small molecules within these host structures, and the release of this cargo when specific DNA strands are added will be shown.\u00a0 We will also describe the use of these cages for the anisotropic organization of transition metals and hydrophobic units, thus defining new modes of protein-inspired interactions. These compact 3D-DNA structures can travel across the plasma membrane of a number of mammalian cells and result in efficient gene silencing. The molecules shown here represent a new class of selective cellular probes and drug delivery tools, and can assist the development of nucleic acid therapeutic routes.\u00a0<\/p>\n<p><strong>R\u00e9f\u00e9rences s\u00e9lectionn\u00e9es :<\/strong><em> Science<\/em>, <strong>2008<\/strong>, <em>321<\/em>, 1795; <em>Nature Chem.<\/em> <strong>2013<\/strong>, <em>5<\/em>, 868; <em>J. Am. Chem. Soc.<\/em> <strong>2013<\/strong>, <em>135<\/em>, 11283; <em>ACS Nano<\/em> <strong>2013<\/strong>, <em>7<\/em>, 3022; <em>Chem. Sci.<\/em> <strong>2012<\/strong>, <em>3<\/em>, 1980; \u00a0<em>J. Am. Chem. Soc.<\/em> <strong>2012<\/strong>, <em>134<\/em> 14382; <em>J. Am. Chem. Soc.<\/em> <strong>2012<\/strong>, <em>134<\/em>, 4280; J<em>. Am. Chem. Soc.<\/em> <strong>2012<\/strong>, <em>134<\/em>, 2888; <em>J. Am. Chem. Soc.<\/em> <strong>2010<\/strong>, <em>132<\/em>, 10212; <em>Nature Chem.<\/em> <strong>2010<\/strong>, <em>2<\/em>, 319; <em>Nature Chem.<\/em> <strong>2009<\/strong>, <em>1<\/em>, 390; <em>Nature Nanotech.<\/em> <strong>2009<\/strong>, <em>4<\/em>, 349; <em>J. Am. Chem. Soc.<\/em> <strong>2007<\/strong>, <em>129<\/em>, 13376.\u00a0 <\/p>\n<p><a href=\"http:\/\/www.hanadisleiman.com\">Information suppl\u00e9mentaire<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Titre :\u00a0 Three-Dimensional DNA Structures for Biological and Materials Applications. La conf\u00e9rence sera prononc\u00e9e par la professeure Hanadi Sleiman du D\u00e9partement de chimie de l&rsquo;Universit\u00e9 McGill. Elle sera donn\u00e9e en anglais.\u00a0 R\u00e9sum\u00e9 : Three-dimensional structures made of DNA hold the potential to encapsulate and release drugs, regulate the assembly and activity of proteins,and organize networks [&hellip;]<\/p>\n<p><a href=\"https:\/\/dev.totemweb.design\/macommunaute\/evenements\/u10131-conference-de-la-professeure-hanadi-sleiman-mcgill\/\">read more<\/a><\/p>","protected":false},"author":14260,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","thematiques":[],"regions":[80],"class_list":["post-173932","evenements","type-evenements","status-publish","hentry","regions-montreal"],"acf":{"evenement_date":"2014-01-22","evenement_date_fin":"2014-01-22","evenement_heure_debut":"11:00:00","evenement_heure_fin":"12:30:00","evenement_recurrence":false,"evenement_recurrence_jours":1,"evenement_recurrence_hebdomadaire":[],"evenement_recurrence_mensuelle_2":[],"evenement_recurrence_fin":null,"evenement_lieu":"","evenement_adresse":"","evenement_site_web":"","evenement_inscription":"","evenement_couts":false,"evenement_frais":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Conf\u00e9rence de la Professeure Hanadi Sleiman (McGill) - Ma Communaut\u00e9<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Conf\u00e9rence de la Professeure Hanadi Sleiman (McGill) - Ma Communaut\u00e9\" \/>\n<meta property=\"og:description\" content=\"Titre :\u00a0 Three-Dimensional DNA Structures for Biological and Materials Applications. 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